Triple-agonist peptide reference
Retatrutide: Reconstitution Math & Reference
By Baris Bingor · Last updated
How do you reconstitute retatrutide?
Retatrutide reconstitution is the same arithmetic as any lyophilized peptide: divide vial mass (mg) by added bacteriostatic water (ml) to get mg/ml. A 10 mg vial in 2 ml BAC water yields 5 mg/ml — so a 2 mg target draw is 0.4 ml, or 40 units on a U-100 syringe. Peptly computes this instantly with a visual draw indicator.
What is Retatrutide?
Retatrutide (LY3437943) is an investigational triple-hormone-receptor agonist — it targets the GLP-1, GIP, AND glucagon receptors. It is a synthetic peptide still in clinical trials.
Retatrutide is investigational and NOT FDA-approved — it remains in clinical trials. A 2023 Phase 2 trial published in the New England Journal of Medicine reported mean weight reductions up to roughly 24% at 48 weeks on the highest (12 mg) dose. Peptly is a calculator for research and reference, not a prescription substitute or dosing advice.
As a triple agonist (GLP-1 + GIP + glucagon), retatrutide is distinct from dual agonists like tirzepatide (GLP-1 + GIP) and single GLP-1 agonists like semaglutide. There is no FDA-approved titration schedule; research protocols follow the published trial literature.
Research-grade retatrutide commonly ships as 5 mg or 10 mg lyophilized powder. The reconstitution math is identical to every other peptide — concentration = vial mass ÷ BAC water. Peptly tracks it as its own profile with saved mixes and an injection log.
Reconstitution math — reference table
| Vial | BAC water | Concentration | Example dose | U-100 units |
|---|---|---|---|---|
| 5 mg | 1 ml | 5 mg/ml | 1 mg | 20 units |
| 5 mg | 2 ml | 2.5 mg/ml | 1 mg | 40 units |
| 10 mg | 2 ml | 5 mg/ml | 2 mg | 40 units |
| 10 mg | 2 ml | 5 mg/ml | 4 mg | 80 units |
| 10 mg | 5 ml | 2 mg/ml | 2 mg | 100 units |
Storage and shelf-life
Reconstituted GLP-1-class peptides are most commonly refrigerated at 2–8 °C and used within 4–6 weeks per common research protocols. Lyophilized powder typically stores at −20 °C until reconstitution.
How Peptly handles Retatrutide
- Pre-loaded compound profile — no manual entry of vial mass each time.
- Saved reconstitution mixes — reload any combination in one tap.
- Visual U-100 syringe view — see the draw mark before you pull it.
- Injection log — every shot, site, and cycle stored on-device.
- Smart reminders — schedule-aware notifications with site rotation prompts.
Other peptide references
- BPC-157 reconstitution math — BPC-157 is a synthetic pentadecapeptide — a 15-amino-acid fragment derived from a protective protein originally isolated from human gastric juice.
- TB-500 reconstitution math — TB-500 is a 17-amino-acid synthetic peptide fragment of Thymosin Beta-4, a regulatory peptide naturally present in most mammalian cells.
- Semaglutide reconstitution math — Semaglutide is a 31-amino-acid GLP-1 receptor agonist.
- Tirzepatide reconstitution math — Tirzepatide is a dual GIP/GLP-1 receptor agonist — a 39-amino-acid synthetic peptide.
- Ipamorelin reconstitution math — Ipamorelin is a 5-amino-acid synthetic peptide and a selective growth hormone secretagogue.
- CJC-1295 reconstitution math — CJC-1295 is a synthetic 30-amino-acid analog of growth hormone-releasing hormone (GHRH 1-29), modified for protease resistance.
- Tesamorelin reconstitution math — Tesamorelin is a synthetic 44-amino-acid analog of human growth hormone-releasing hormone (GHRH 1-44), stabilized with a trans-3-hexenoic acid group.
- GHK-Cu reconstitution math — GHK-Cu is a copper complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys), which binds a single copper(II) ion.
Related tools and guides
- Main peptide calculator overview
- Peptide reconstitution math reference
- BAC water calculator
- Step-by-step reconstitution guide
- Peptide storage & refrigeration guide
- Peptide dosage unit reference
- Peptide tracker — injection log
Frequently asked questions
How is retatrutide different from tirzepatide and semaglutide? +
Retatrutide is a triple agonist (GLP-1 + GIP + glucagon). Tirzepatide is a dual agonist (GLP-1 + GIP); semaglutide is a single GLP-1 agonist. The reconstitution math is identical for all three — only the receptor targets and dose ranges differ.
What BAC water volume works for a 10 mg retatrutide vial? +
Common starting points are 1 ml (10 mg/ml) or 2 ml (5 mg/ml). At 5 mg/ml, a 2 mg research draw is 40 units on a U-100 syringe. Peptly shows the unit count for any vial × water combination live as you adjust the BAC slider.
Is there an approved retatrutide dosing schedule? +
No. Retatrutide is investigational and has no FDA-approved label or titration schedule. Research protocols follow the published clinical-trial literature. Peptly does not recommend a dose — it only does the reconstitution arithmetic.
Can Peptly track a retatrutide research cycle? +
Yes. In Peptly Pro you can save the reconstitution mix and log each weekly shot with site rotation. The History view keeps retatrutide separate from any other peptide profile.
Is retatrutide approved for human use? +
No. Retatrutide (LY3437943) is investigational and not FDA-approved; it remains in clinical trials. Peptly is a calculator and reference tool, not medical advice. Consult a licensed clinician for any health decision.